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The proceedings will be recorded and an official written summary will be prepared. The resident will have the opportunity to be present when the witnesses are questioned and to question them personally. The resident will be provided the opportunity to present such documentary evidence as might be relevant to the case. Formal rules of evidence will not be followed, but the committee will allow into evidence any information that they believe will be of probative value in deciding the issues. While the resident will be present throughout the proceedings, the committee will conduct its deliberations in private. Residents will be allowed to challenge the participation of any committee member for cause. After a departmental decision has been rendered, the resident may appeal that decision to the Dean of the School of Medicine. Within ten (10) working days after receiving the written appeal, the Dean shall refer the matter to the ad hoc faculty committee of three to five persons who shall review the appeal and make recommendations to the Dean. The Dean shall review the recommendations of the committee and render a final decision thereon and notify the house officer and the Chairman of his department in writing within ten (10) working days. Within ten (10) working days, the President shall advise the house officer in writing of his final decision. The application for review shall be submitted in writing to the Executive Secretary of the Board within a period of twenty days following the decision of the president. A review by the Board is not a matter of right, but is within the sound discretion of the Board. If the application for review is granted, the Board or a committee of the Board or a Hearing Officer appointed by the Board, shall investigate the matter thoroughly and report its findings and recommendations to the Board. The Board shall render its decision thereon within sixty days from the filing date of the application for review or from the date of any hearing that may be held thereon. There are resident level specific goals and objectives in each section that should be reviewed prior to each rotation. The dictated reports should be accurate, concise and contain appropriate level of detail 5. Discuss results with referring physicians or appropriate team members with documentation of critical results in exam report 7. M, or after lecture when applicable, and throughout the work day, completion of dictation of all reviewed studies in a timely manner, attendance at all departmental teaching conferences, and grand rounds presentations. Learn the basic principles of contrast distribution particularly as applied to arterial and venous phase scanning. Learn principals and guidelines for imaging pregnant patients in emergency setting. Understand the principles of computed tomographic angiography Be able to identify life-threatening findings, particular in trauma patients Provide emergent provisional interpretation as needed Be able to direct the choice of imaging modality and protocol emergent studies Understand where referral to other imaging modalities is necessary. The resident is also expected to learn by teaching the medical students on service. In the unusual case of substandard performance, the evaluation will be brought to the attention of the Program Director and the resident for further counseling. Learn and demonstrate knowledge of radiation protection and ways to reduce radiation exposure to both patients and hospital personnel. The resident will be appropriately supervised to assure that safe practices are adhered to. Become knowledgeable about the use of different radiographic contrast agents, including their indications, contraindications, dosages, side effects, treatment of adverse reactions and contrast allergy prevention/premedication techniques. Demonstrate proficiency at detecting abnormalities demonstrated by chest and abdominal scout plain films. Acquire an understanding of the proper preparation of patients for fluoroscopic examinations and appropriate follow-up afterwards.

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He has worked as a farmer for many years, and sometimes his grain has become moldy. A biopsy of this mass is diagnosed as a moderately differentiated squamous cell carcinoma. Mention the sequence of events that precedes the formation of an infiltrating squamous cell carcinoma of the cervix? A 20-year-old woman notes a mass in her left breast after following the directions for breast self-examination provided by her health clinic. Her left breast is slightly larger than the right, a condition she says has been present since puberty. Mammography confirms the presence of an rounded density, which has no microcalcifications, and reveals no lesions of the opposite breast. A - Focus of fat necrosis B - Fibroadenoma C - Intraductal papilloma D - Infiltrating ductal carcinoma E - Cystosarcoma phyllodes 9. A 55-year-old man with a 55 pack year history of smoking cigarettes has recently experienced an episode of hemoptysis along with his usual cough. He has a sputum cytology examination performed that on microscopic examination shows atypical cells with hyperchromatic nuclei and orange-pink cytoplasm. Which of the following chest radiographic findings is this man most likely to have? A - Large hilar mass D - Carinal compression B - Pneumonia-like consolidation C - Peripheral nodule E - Left pleural thickening 10. A 61-year-old man has had a chronic cough for 6 years as a result of smoking 2 packs of cigarettes per day for 45 years. Which of the following microscopic appearances is most likely to be present in this biopsy? A - Organizing abscess B - Viral inclusions C - Plaque of demyelination D - Neuronal loss with gliosis E - Metastatic carcinoma 11. Her left breast is slightly larger than the right; a condition she says has been present since puberty. Mammography confirms the presence of a rounded density, which has no microcalcifications, and reveals no lesions of the opposite breast. A 35-year-old man living in a southern region of Africa presents with increasing abdominal pain and jaundice. Physical examination reveals a large mass involving the right side of his liver, and a biopsy specimen from this mass confirms the diagnosis of liver cancer (hepatocellular carcinoma). Which of the following substances is most closely associated with the pathogenesis of this tumor? As a physician, you should be concerned about a surgical pathology report that describes severe dysplasia in a biopsy because: a-this change indicates irreversible tissue damage b- it may be due to irritant that can be avoided c-the patient will probably develop cancer d- it may be due to viral infection that can be treated e- any of the above 14. You are reading a histopathology report which describes the excised tumour as malignant round cell tumour. On physical examination, she is febrile, and palpation of the abdomen shows a tender mass on the right loin. A 60-year-old woman has reported a change in the caliber of her stools during the past month. On physical examination, there are no abnormal findings, but a stool sample is positive for occult blood. A colonoscopy shows a constricting mass involving the lower sigmoid colon, and the patient undergoes a partial colectomy. Which of the following techniques used during surgery can best aid the surgeon in determining whether the resection is adequate to reduce the probability of a recurrence? You are reading a histopathology report which describes the excised tumour as undifferentiated malignant neoplasm. Genetic predisposition to cancer 9- Describe the pathological features, outcome and prognostic factors of hepatoblastoma.


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Mismatch repair deficiency gives rise to microsatellite instability, and as such may aid in the diagnosis of this syndrome . In particular, it is also able to recognize lesions caused by exogenous mutagens, and has been shown to participate in transcription-coupled repair {134, 1215}. Commonly used theoretical criteria in support of pathogenicity include the following: the mutation leads to a nonconservative amino acid change, the involved codon is evolutionarily conserved, the change is absent in the normal population, and it segregates with the disease phenotype. A subset of such mutations was directly assessed for pathogenicity using a yeastbased functional assay, and there was a good correlation . There is no clear-cut correlation between the involved gene, mutation site within the gene, or mutation type vs. Finally, capability of the mutant protein to block the normal homologue by a dominant negative fashion may lead to a severe phenotype, in which even normal cells may manifest mismatch repair deficiency {1475, 1348}. Conversely, inability to do so may be associated with a milder phenotype and lack of extracolonic cancers . Other syndromes that display hamartomatous gastrointestinal polyps should be ruled out clinically or by pathological examination. Patients with juvenile polyposis usually present with gastrointestinal bleeding, manifesting as haematochezia. Melaena, prolapsed rectal polyps, passage of tissue per rectum, intussusception, abdominal pain, and anaemia are also common. Air contrast barium enema and upper gastrointestinal series may demonstrate filling defects, but are non-diagnostic for juvenile polyps. Biopsy or excision of polyps by colonoscopy can be both diagnostic and therapeutic. Small juvenile polyps may resemble hyperplastic polyps, while larger polyps generally have a welldefined stalk with a bright red, rounded head, which may be eroded. Macroscopy Most subjects with juvenile polyposis have between 50-200 polyps throughout the colorectum. The rare and often lethal form occurring in infancy may be associated with a diffuse gastrointestinal polyposis . In cases presenting in later childhood to adulthood, completely unaffected mucosa separates the lesions. This is unlike the dense mucosal carpeting that is characteristic of familial adenomatous polyposis. The individual lobes are relatively smooth and separated by deep, well-defined clefts. The multilobated polyp therefore appears like a cluster of smaller juvenile polyps attached to a common stalk. Such multilobated or atypical juvenile polyps account for about 20% of the total number of polyps . A B Age and sex distribution Two-thirds of patients with juvenile polyposis present within the first 2 decades of life, with a mean age at diagnosis of 18. Though extensive epidemiological data do not exist, incomplete penetrance and approximately equal distribution between the sexes can be presumed. Localization Polyps occur with equal frequency throughout the colon and may range in number from one to more than a hundred. Some patients develop upper gastrointestinal tract polyps, most often in the stomach, but also in the small intestine. Generalized juvenile gastrointestinal polyposis is defined by the presence of C. The contour of polyps is highly irregular, fronded, in contrast to solitary sporadic juvenile polyps. The bizarre architecture differs from the round, uniform structure of sporadic juvenile polyps. A B Histopathology Smaller polyps are indistinguishable from their sporadic counterparts.

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As such, understanding the mechanistic pathways that contribute to changes in the morphology or number of lipid droplets is an important step toward developing therapeutic interventions for these diseases. Culture human conditionally immortalized podocytes as described in [19] (see Note 1). At the appropriate time point, add 50 l of media containing treatment at 4В the desired final concentration. Imaging a plane closer to bottom surface of the cells will result in sharper images with low background. It will also provide a section of the cell body with minimal cytoplasmic breaks, which will facilitate cell segmentation. We recommend using -clear 96-well Greiner plates and visualizing the lipid droplets with the 20В magnification lens. Acquire 20­30 different fields or enough fields to count at least individual 200 cells per well. Nuclei detection: locating regions belonging to nuclei in the image is the first step in identifying and segmenting their corresponding cell bodies. Cells marked with green were selected for further analysis, and cells marked with red were removed from the analysis; (e) spot detection. Navigate to the image analysis tab in the top menu, and select "find nuclei" from the drop-down menu to create the first step in the image analysis pipeline. After selecting the nuclear channel (in this case, channel-1), select algorithm B with common threshold 0. Proper identification of the nuclei must be confirmed by manually checking 5­10 images. Once executed, this step will identify the nuclei within an image, which will be referred to by the default name of "total cells" (see Note 7). Cell segmentation: in this step, cell bodies are identified by detecting areas surrounding nuclei with staining intensity in the deep red (640 nm) channel, followed by the application of a watershed algorithm to separate neighboring cells along their borders. Similar to nuclei detection, select the appropriate channel (in this case, channel-3). Method D works best when intensity decreases with the distance from nucleus and cells are in higher density. In sparse cells cultures, errors may occur with the detected cytoplasm spreading out to the background area, and a different algorithm may be required. Exclusion of artifacts: cells which are largely outside the border of the image may skew the analysis and must be excluded. From drop-down menu, select nuclei as the population and common filter as the method. Additional removal of artifacts can be accomplished in subsequent steps following the calculation of morphological properties. Calculation of morphological properties: add a "Calculate morphology properties" step to compute the morphological properties of the selected cells. From the drop-down menu, select cell area and input the appropriate minimum area in M2. Spot detection: spots are defined as small regions on the image having a higher intensity than their surroundings. Correct identification of the spots should be manually checked in 5­10 figures, and the method parameters tweaked as necessary (see Note 9). For differentiation, cells at 40­60% confluence are thermoshifted to 37 C and maintained for 14 days. For multiplex staining with any given combination of dyes, the choice and concentration of each individual dye must be optimized for the corresponding imaging system to minimize bleed through across different channels. Although a single dye like CellMask Deep Red or CellMask Blue can be used for both nucleus and cytosol staining, we have found that using a different dye/channel for each result in superior nuclear detection and cell segmentation. We observe that after 15 days at 4 C, fluorescence intensity of stained cells decreases by 60­70%. In the Columbus software, it is important to remove unwanted cells after cell segmentation. Removing unwanted nuclei before defining the cytoplasm will affect your cell segmentation. Depending on the dye, cells types, and method of staining, background intensity varies, and it is important to fine-tune the identification criteria during each experiment.

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Nov 3809(Online), 24550558(P rint) 6 11 765767 68 Evidence Based Community Health Project; Faculty Perception on its effectiveness, outcomes and implementation 69 Study of factors affecting Noncompliance to Anti-psychotic medications in patients with Psychotic illness. Sunil; Pathak Staphylococcal Scalded Skin Syndrome in a Newborn- A Case Report International Archives of Integrated Medicine Both National 23940026 (P) 23940034 (O) Dez. Rishit A Pathological Soni fracture in Simple Bone Cyst of Scaphoid International Journal of advanced Research Online International 23205407 (O) Dez. Som Mimicking Lakhani Sexually Transmitted Infection (Case Report) Journal of Integrated Health Sciences Both National 23476486 (P) 23476494 (O) Dez. Chirag Kapoor Journal of Clinical Orthopaedics and Trauma Online National 09765662 (O) Sep. Shah the Southeast Asian Journal of Case Report and Review Online International 23191090 (O) Okt. Jaswant Schonleinpurpu Mahawer ra with Sickle Cell Disease- A Rare Presentation Indian Journal of Applied Research Online National 2249555x (O) Okt. Jagdish of rolled tendon Patwa arthroplasty in carpometacarpal joint arthritis of thumb International Archives of Integrated Medicine Both National 23940026 (P) 23940034 (O) Okt. Anil Roy Journal of Integrated Health Sciences Both National 23476486 (P) 23476494 (O) Dez. Hetal Pandya, Pabani N, Shah K, Yadav R, Patel P, Raninga J Journal of Integrated Health Sciences Both National 23476486 (P) 23476494 (O) Dez. Indian Journal of Basic and Applied Medical Research Both National 2250 - 2014 2858 3 3 212215 Index ijba ijbam Copernicus mr. Sep GoogleGlo bal Impact Facto,India n Science,Go ogle Scholar Index Copernicus Google Scholar Index Copernicus Global Impact Factor Indian Science Journals4fr ee Sciencecen tral ssjou rnals. Bhagya Nerve Condution; Manoj Sattigeri Electrochemistry; Future Prospects Int J Res Med Sci. Gunvanti efficacy of fine Rathod needle aspiration cytology in cervical lymphadenopath y ­ a one year study Effective podium Dr. Rathod presentation Suprascapular malignant fibrous histiocytoma Blackboard as tool for teaching ending of golden era Dr. Rathod radicals-invarious-aspectsof-health-areview-snuL Power point for presentations Important tips Dr. Lakhani & Radhika Khara International online journal of biological & medical research Internatio 0976- 2014 nal 6685 5 2 4089- google 4092 scholar, index copernicus, research gate, medline plus, medbio world ww w. Mangal3, Kunal Pipalia3, Viral Aghera3, Dipen Dabhi3 1Department of Forensic medicine, Smt. Shah Medical Institute and research centre, Vadodara; 2Department of Forensic medicine, C. Kothari, Shridhar Rawal Shridhar Rawal International both Journal of Health science and Research International 22499571 Febrary 4 2014 2 86-90 Scopemed, index copernicus Alpa Patel Asst Indian journal of Both Prof Ophthal Dept Health sciences & Reasearch International 22499571 Jдn. Deepak Patel Associate Health sciences & Reasearch Prof Ophthal Dept International 22499572 Feb. Efficacy of limbal conjunctiva l autograft surgery with stem cells in primary and recurrentpt erygium. Nisarg Shah Journal of Evolution of Medical and Dental Sciences Print and National Online e-2278- 2014 4802 3 2 416421 Google Scholar 0 jemd s. Parmar (Ex Prof) (Anesthesia) Internation journal of biomedical and advance research Online National 22293809 Apr. Bhavsar Mrugank(R3) (Anaesthesia) International Online Journal of Reproduction, Contraception, Obstetrics and Gynecology National p 2320- Sep. Trushna Shah Biochemistry Assessment of Obesity, Overweight and Its Association with the Fast Food Consumption in Medical Students Elevated Serum ferritin in type 2 diabetes mellitus and its relationship with hbaic Journal of Clinical and Diagnostic Research Journal of Medical Science & Technology National Journal of Integrated Research in Medicine Transworld Medical Journal Pubmed. Gunvanti Rathod Pathology Suprascapular malignant fibroushistiocytoma - A case report Study of knowledge, attitude and practice of general population of waghodia towards diabetes mellitus Discovery Publication Medline.


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Circumferential measurements of both extremities should be taken at the metacarpal-phalangeal joints, the wrists, 10 cm distal and 15 cm proximal to the lateral epicondyles at baseline and after treatment. Symptoms will include swelling on the same side of treatment, sensation of heaviness of the limb, fatigue, fullness/tightness of skin or pain. Options of care include: external compression garments (such as lymphedema stockings), massage/ manual lymphatic drainage, elevation, exercise, psychosocial support and prompt treatment of infections. Breast reconstruction: Every patient undergoing mastectomy should be informed of the option of breast reconstruction for patients with early breast cancer or locally advanced breast cancer as appropriate. Breast prostheses may be considered for breast cancers survivors who have undergone mastectomy. Management of hormone-related symptoms: menopause management in females by appropriate specialist. Symptom management ­ pain, wound management, depression, anaemia, side effects of their medication, loss of appetite, vomiting, numbness. Sexuality support and management should be discussed and if needed patient sent to experts for management. Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy. The annual global age-standardized incidence of primary malignant brain tumors is ~3. In adults, two thirds of primary brain tumors arise from supratentorial region with gliomas, metastases, meningiomas, pituitary adenomas and acoustic neuromas accounting for 95% of all brain tumors. The referring health care provider should inform the health care provider at the receiving facility about the referral and write a comprehensive medical report to accompany the patient including all scans done. Biopsy: Tissue obtained at emergency or elective surgery should be submitted to histopathology for examination. Diagnostic biopsy is required before initiation of any chemotherapy or radio therapy, except for high-risk cases where biopsy cannot be done and emergency radiotherapy is required. Immunohistochemistry is recommended for confirmation of diagnosis, being mandatory for high-grade or equivocal tumors where the histogenesis is unclear. For long term treatment, carbamazepine or lamotrigine may be used for focal onset seizures and sodium valproate or lamotrigine for primary generalized seizures. Definitive Management Maximal safe debulking surgery is the initial standard of care to relieve mass effect, obtain diagnostic tissue, reduce tumor burden and to improve or maintain neurological status. Confirmed histological diagnosis and oncology review should be within ten days of surgery due to the rapid doubling time of the tumor. Adjuvant treatment such as radiotherapy with concurrent chemotherapy may be required. Recurrent Disease/ Progression Surgery is indicated in selected patients to relieve symptoms, improve performance status and quality of life. Repeat radiotherapy may be considered, depending on size of lesion, previous dose and the interval since the last radiotherapy treatment. Active agents include Carmustine, Vincristine, Temozolomide, Irinotecan and Bevacizumab. Thereafter scans are usually done at 6 months and then annually, or if clinically indicated. Management Surgery is the primary treatment for most pituitary tumors (except prolactinomas which may be managed medically). Radiotherapy is indicated for sub totally resected tumors, recurrent tumors, patients with persistently elevated circulating hormone levels, and medically inoperable patients. It is very effective for control of growth of pituitary tumors (>95%), but is less effective for decreasing circulating hormone levels of endocrinologically active tumors whose control may take years to achieve after radiotherapy. Possible etiologies include previous exposure to ionizing radiation, trauma, viral infections and exposure to sex hormones (approx. It is often associated with linear meningeal thickening ("dural tail"), which frequently represents reactive change but may represent spread along meningeal plane. Imaging may give an indication as to the grade of the meningioma with the lesions with predominant surrounding edema being higher grade. Radiotherapy Post-operative radiotherapy significantly improves survival rates and is standard of care.

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A nearly equal incidence of tumors involving the alveolar ridge and maxillary antrum is found in the maxilla, with few cases affecting the palate. The most common presentation of jaw osteosarcoma is localized pain and swelling and in some cases, loosening and displacement of teeth may occur. Paresthesia, frequently a cardinal sign of malignancy, is caused by compression or infiltration of adjacent nerves by tumor. Maxillary tumors display similar clinical symptoms but may also cause epistaxis, nasal obstruction, or eye problems such as proptosis and diplopia. The radiographic appearance of conventional (intramedullary) osteosarcoma is variable, reflecting the irregular tumor growth pattern, the effect on adjacent normal structures, and the amount of calcification within the tumor. There appears to be little relationship between the radiographic pattern and the histologic subtype of osteosarcoma. Early osteosarcomas that involve the alveolar process may be characterized by localized widening of the periodontal ligament space of one or two teeth (Figures 14-1 and 14-2). The widened space results from tumor invasion of the periodontal ligament and resorption of surrounding alveolar bone (Figure 14-3). Advanced tumors can appear as "moth-eaten" radiolucencies or as irregular, poorly marginated radiopacities. A characteristic "sunray" or "sunburst" radiopaque appearance due to periosteal reaction may be seen in jaw lesions but is not diagnostic of osteosarcoma (Figures 14-4 and 14-5). Histopathology Microscopically, all osteosarcomas have in common a sarcomatous (malignant spindle cell) stroma that directly Similar to their counterpart in the long bones, conventional osteosarcomas involving the mandible and maxilla display a slight predilection for males (60%). Although the peak incidence of osteosarcoma of the skeleton occurs in the second decade, cases arising in the jaws generally present one to two decades later, with a mean age of 35 years (range, 8-85 years). A majority (60%) of mandibular osteosarcomas arise in · Figure 14-1 Osteosarcoma surrounding the roots of the first molar tooth. B and C, Surgical specimen shows a malignant bone-producing neoplasm occupying the periodontal ligament space. Osteosarcoma of the mandible exhibiting sunburst · Figure 14-4 Osteosarcoma of the mandible showing a sunburst pattern of tumor bone radiating from the alveolar ridge. A · Figure 14-6 B A and B, Osteosarcoma composed of atypical cells in association with tumor bone. Histologic subtypes are recognized and have been designated as chondroblastic when formed malignant cartilage predominates (most common) (Figure 14-8), osteoblastic when malignant bone and osteoid predominate, and fibroblastic when spindle cells predominate (Figure 14-9). An additional variant, designated as telangiectatic, contains multiple blood-filled aneurysmal spaces lined by malignant cells but rarely occurs in the head and neck region. Some osteosarcomas contain multinucleated giant cells so plentiful that this form may be mistaken for a central giant cell granuloma. Central low-grade osteosarcoma is a rare variant, accounting for 1% of all osteosarcomas, that may involve the jaws. Microscopically, it resembles fibrous dysplasia because of the minimally atypical spindle cell proliferation with occasional mitotic figures and bone spicules. The microscopic diagnosis poses a challenge because of its deceptively bland features. Unlike fibrous dysplasia, the radiographic appearance is poorly marginated with cortical disruption, variable mineralization, and with absent margin sclerosis. Also unlike fibrous dysplasia, the proliferation permeates bone marrow, may extend through the periosteum, and may invade soft tissues. Immunohistochemistry for the nuclear · Figure 14-7 Osteosarcoma exhibiting a partially myxoid microscopic appearance. Recurrent tumor or long-standing low-grade osteosarcoma may transform to conventional high-grade osteosarcoma (Figure 14-10). All histologic variants of conventional osteosarcoma reflect the multipotentiality of neoplastic mesenchymal cells in producing osteoid, cartilage, and fibrous tissue (see Attempts to further grade conventional intramedullary osteosarcomas are often problematic because of the heterogeneity of tumor morphology and, with the exception of central low-grade osteosarcoma, have proved to have little prognostic value. Differential Diagnosis Uniform widening of the periodontal ligament space of involved teeth appears to be characteristic of early osteosarcoma that involves the alveolus. However, this focal radiographic defect may also be seen with other malignancies surrounding the teeth. Moth-eaten radiolucencies are common to other malignancies, chronic osteomyelitis, and several benign neoplasms.

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This combination of ingredients, which may vary from one locale to another, is more carcinogenic than tobacco used alone. Etiology Of all factors believed to contribute to the etiology of oral cancer, tobacco is regarded as the most important. All forms of tobacco smoking have been strongly linked to the cause of oral cancer. Smoking of cigars and pipes is linked to greater risk for the development of oral cancer than that associated with cigarette smoking. This high risk is due to the intensity of tobacco combustion adjacent to palatal and lingual tissues. In any event, the time-dose relationship of carcinogens found in tobacco is of paramount importance in determining the cause of oral cancer. In addition to an overall increased risk of development of cancer in all regions of the mouth, pipe smokers appear to have a special predilection for squamous cell carcinoma of the lower lip. Long-term use of smokeless tobacco, whether in the form of snuff (ground and finely cut tobacco) or chewing tobacco (loose-leaf tobacco), is believed to increase the risk of oral cancer, although the risk level is probably low. In view of this lower oral cancer risk, some have advocated smokeless tobacco or even e-cigarettes as alternatives to conventional cigarettes, although the rationale for this is suspect when safe, alternative smoking cessation methods exist. In addition, many patients who use smokeless tobacco products also consume cigarettes and alcohol, thereby increasing their risk of oral cancer. Moreover, the use of smokeless tobacco carries with it other health risks, such as elevated blood pressure, physiologic dependence, and worsening periodontal disease. Alcohol, although not generally believed to be a carcinogen itself, appears to add to the risk of oral cancer development. Identification of alcohol alone as a carcinogenic factor has proved to be somewhat difficult because of the combination of smoking and drinking habits seen in most patients with oral cancer. However, recent epidemiologic studies suggest that alcohol use alone may increase the risk for oral cancer. The effects of alcohol have been thought to occur through its ability to irritate the mucosa and to act as a solvent for carcinogens (especially those in tobacco). Contaminants and additives with carcinogenic potential that are found in alcoholic drinks have been thought to have a role in the development of oral cancer. Molecular studies have suggested that the carcinogenic risks associated with alcohol may be related to the effects of an alcohol metabolite, acetaldehyde, through alteration of keratinocyte gene expression. Candida albicans has been suggested as a possible causative agent because of its potential to produce a carcinogen, N-nitrosobenzylmethylamine. Although poor nutritional status has been linked to an increased rise in oral cancer, the only convincing nutritional factor that has been associated with oral cancer is iron deficiency of Plummer-Vinson syndrome (also called PattersonKelly syndrome or sideropenic dysphagia). Typically affecting middle-aged women, the syndrome includes a painful red tongue, mucosal atrophy, dysphagia caused by esophageal webs, and a predisposition to the development of oral squamous cell carcinoma. The cumulative dose of sunlight and the amount of protection by natural pigmentation are of great significance in the development of these cancers. This increased risk has been documented for bone marrow and kidney transplant recipients, who are iatrogenically immunosuppressed. The total-body radiation and high-dose chemotherapy that are used to condition patients for bone marrow transplants also put patients at lifelong risk for solid and lymphoid malignancies. Chronic irritation is generally regarded as a modifier rather than an initiator of oral cancer. Mechanical trauma from ill-fitting dentures, broken fillings, and other frictional rubs is unlikely to cause oral cancer. If a cancer is started from another cause, these factors will probably hasten the process. Poor oral hygiene is regarded as having a comparable modifying effect, although many patients with poor oral hygiene have other more important risk factors for oral cancer, such as tobacco habits and alcohol consumption. Pathogenesis Oral cancer, similar to most other malignancies, arises from the accumulation of a number of discrete genetic events that lead to invasive cancer (Figures 2-56 to 2-58). These changes occur in genes that encode for proteins that control the cell cycle, cell survival, cell motility, and angiogenesis.

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Squamous cell carcinoma of the esophagus is an aggressive cancer with rapid progression and short survival in all stages of disease. This condition most commonly occurs in male infants within the first several days to weeks of life. Crohn disease and ulcerative colitis are the two classic inflammatory bowel diseases. Adenocarcinoma of the colon most commonly develops through a progression of mutations in oncogenes and tumor suppressor genes in a multistep process. Normal mucosa evolves into a tubular adenoma with malignant potential, which then further evolves into carcinoma (the adenoma-carcinoma sequence). Carcinoma of the rectosigmoid (left-sided) tends to present as early obstruction, with change in bowel habits and decreased caliber of stool, whereas carcinoma of the right colon (right-sided) tends to present late, with iron deficiency anemia due to chronic blood loss from the lesion. This organism produces exotoxin that induces necrosis of the superficial mucosa, leading to pseudomembrane formation. The illustration demonstrates diverticulosis of the colon (openings shown by arrows). In contrast to carcinoma, peptic ulcer will usually heal with conservative management. The illustration shows a tubular adenoma, which is the most common form of adenomatous polyp. These lesions can be single or multiple, or they can occur as components of various multiple polyposis syndromes. Even though the polyp itself does not transform into colon cancer, the Peutz-Jeghers syndrome is associated with an increased incidence of colon cancer and malignancies elsewhere. E-cadherin mutations account for a significant proportion of familial gastric cancers and are also implicated in lobular carcinoma of the breast. Although Lynch syndrome patients are at increased risk for gastric adenocarcinoma, their tumors are typically conventional, rather than signet-ring, in morphology. Hyperplastic polyps, Peutz-Jeghers polyps, and inflammatory polyps are not malignant precursors. It is most often associated with hepatocellular disease, biliary obstruction, or hemolytic anemia. Physiologic jaundice of the newborn is commonly noted during the first week of life, but is not usually clinically important. This form of jaundice results from both increased bilirubin production and a relative deficiency of glucuronyl transferase in the immature liver; these phenomena are exaggerated in premature infants. Physiologic jaundice of the newborn must be distinguished from neonatal cholestasis, which is due to a wide variety of causes, including extrahepatic biliary atresia, 1-antitrypsin deficiency, cytomegalovirus infection, and many other conditions. Crigler-Najjar syndrome is a severe familial disorder characterized by unconjugated hyperbilirubinemia caused by a deficiency of glucuronyl transferase. Dubin-Johnson syndrome is an autosomal recessive form of conjugated hyperbilirubinemia characterized by defective bilirubin transport. The deposition of black melanin-like pigment in hepatocytes and Kupffer cells differentiates this condition from other congenital conjugated hyperbilirubinemias. The sequence in which the various antigens or antibodies to these antigens appear in the serum is of clinical significance. Yellow fever characteristically demonstrates a severe hepatitic component marked by midzonal hepatic necrosis. Similar inclusions are observed in all of the viral hepatitides and are manifestations of apoptosis. Leptospirosis, also known as Weil disease or icterohemorrhagic fever, is caused by Leptospira species. Echinococcus granulosus infestation is caused by ingestion of tapeworm eggs from the excreta of dogs and sheep. The eggs are highly antigenic and stimulate granuloma formation, with resultant tissue destruction, scarring, and portal hypertension. This acute disorder of young children is characterized by encephalopathy, coma, and b.

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Subcutaneous emphysema was observed in 3 patients each in Groups 1 and 4, 4 patients in Group 3, and 2 patients in Group 2. These did not affect our clinical followup strategies or need additional interventions. Well known benefits[14] and complications[15] of laparoscopic surgery have been revealed. Additionally, laparoscopy can be performed for most of the urological surgery modalities in pioneer centres today[16]. In this case, some ventilation and medical interventions may come into question[17]. Nevertheless, if urologists perform laparoscopy, they should know how to overcome those complications. According to our data analysis, we believe that transperitoneal route can be safer than retroperitoneal route when the surgical procedure would continue for more than 3 hours. Notably, retroperitoneal space has more absorption capacity than transperitoneal one. Besides, some of the surgeons usually try to provide more space during retroperitoneal laparoscopic surgery. Specifically, when aspiration is used in retroperitoneal space, collapse in operation area comes into question. Therefore, surgeons try to expand surgical space by performing additional dissection in extraperitoneal space[22]. In addition, 58 Impact of Ventilation Modes with Different Laparoscopic Access Routes on Blood Gases. March 2018 use of increased gas pressure can expand surgical space during operation. However, there was no gas embolism, and only subcutaneous emphysema was observed in groups without significant difference. Nevertheless, there was more subcutaneous emphysema in retroperitoneal access route. Our surgeon also performed all procedures with both access types and has similar experience for transperitoneal and retroperitoneal surgeries. Therefore, we believe that we could avoid effect of surgeon and surgical technique on the outcome of the study. We strongly think that choosing laparoscopic approach technique can also help to reduce complications. Besides these, there was significant correlation between delta pH and access route. These can be another reflection of importance of ventilation mode and access route in prolonged laparoscopic operations. Kehlet et al reported that the anaesthetist plays an important role in reducing pain after operation[27]. We think that collaboration with anaesthetist can make operation plausible during the course of operation, as well as during the followup of patient. Additionally, there were low numbers of patients in the groups and selection bias may come into question. Nonetheless, we focused on chancing in parameters of blood gases during laparoscopic surgery. Laparoscopic surgeons usually prefer laparoscopic approaching methods in which they are experienced. Clinicians should also note the changes which occur in the blood gases during operation when prolonged laparoscopic urologic procedures are planned. Impact of laparoscopic radical prostatectomy on clinical t3 prostate cancer: experience of single center with long term follow-up. Effects of retroperitoneal or transperitoneal laparoscopic surgery on hemodynamic and respiratory function in old patients. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. Low tidal volume ventilation in patients without acute respiratory distress syndrome: A paradigm shift in mechanical ventilation. Comparison of transperitoneal and extraperitoneal laparoscopic radical prostatectomy using match-pair analysis.


  • https://www.asthmacenter.com/wp-content/uploads/Sinusitis-manuel-3.1.pdf
  • https://www.jbc.org/content/250/8/2769.full.pdf
  • https://wa.kaiserpermanente.org/static/healthAndWellness/pdf/mrsa.pdf
  • http://www.baylor.edu/content/services/document.php/156373.pdf
  • https://academic.oup.com/bjaed/article-pdf/9/2/65/849548/mkp007.pdf
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